Monday, 10 November 2014

UNRAVELING THE MISTERY: HOW MUCH PHOSPHATE DOES THIS SOLUTION CONTAIN?

POTASSIUM PHOSPHATE solutions world-wide differ significantly in composition. How to calculate how much P is contained in each specific solution?

Note: Monobasic potassium phosphate (KH2PO4) MW 136, dibasic potassium phosphate (K2HPO4) MW 174, 1 mmol P= 31 mg; 1 mmol P=1 mmol PO4


POTASSIUM PHOSPHATES Injection, USP 3 mM P/mL and 4.4 mEq K+/mL (marketed in US)
Each milliliter contains 224 mg of monobasic potassium phosphate, anhydrous and 236 mg of dibasic potassium phosphate, anhydrous. One mM of phosphorus weighs 31 mg and the product provides 93 mg (approximately 3 mM) of phosphorus/mL, plus 170.3 mg (4.4 mEq) of potassium/mL. 


POTASSIUM PHOSPHATE MONICO (marketed in several European countries, including Italy)
Each 10 mL vial contains 300 mg of monobasic potassium phosphate, anhydrous and 1550 mg of dibasic potassium phosphate, anhydrous. A 10 mL vial of this product provides 344 mg (approximately 11 mmol) of phosphorus plus 20 mEq of potassium.

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